RBM15

RBM15
Identifiers
Aliases	RBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15
External IDs	OMIM: 606077; MGI: 2443205; HomoloGene: 23383; GeneCards: RBM15; OMA:RBM15 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,346,681 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,240,989 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; endothelial cell; ; Brodmann area 23; ; gingival epithelium; ; Epithelium of choroid plexus; ; middle temporal gyrus; ; parietal pleura; ; visceral pleura; ; epithelium of nasopharynx;
	Top expressed in
	ciliary body; ; gastrula; ; lacrimal gland; ; submandibular gland; ; abdominal wall; ; primitive streak; ; retinal pigment epithelium; ; fossa; ; endothelial cell of lymphatic vessel; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; mRNA binding;
Cellular component	nuclear speck; nuclear membrane; membrane; nucleus; nucleoplasm; nuclear envelope; RNA N6-methyladenosine methyltransferase complex;
Biological process	branching involved in blood vessel morphogenesis; ventricular septum morphogenesis; mRNA splicing, via spliceosome; placenta blood vessel development; viral process; negative regulation of myeloid cell differentiation; spleen development; negative regulation of transcription, DNA-templated; positive regulation of transcription of Notch receptor target; regulation of alternative mRNA splicing, via spliceosome; RNA methylation; dosage compensation by inactivation of X chromosome; thrombopoietin-mediated signaling pathway; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	64783
	229700
	ENSG00000162775
	ENSMUSG00000048109
	Q96T37
	Q0VBL3
	NM_001201545; NM_022768; NM_014092
	NM_001045807
	NP_001188474; NP_073605
	NP_001039272
	Wikidata
View/Edit Human	View/Edit Mouse

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene. It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs