RBM4

RBM4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DNQ
Identifiers
Aliases	RBM4, LARK, RBM4A, ZCCHC21, ZCRB3A, RNA binding motif protein 4
External IDs	OMIM: 602571; MGI: 1100865; HomoloGene: 82510; GeneCards: RBM4; OMA:RBM4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,668,374 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,843,929 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; body of pancreas; ; right hemisphere of cerebellum; ; right adrenal gland; ; left ovary; ; right ovary; ; right adrenal cortex; ; right lobe of thyroid gland; ; left adrenal gland;
	Top expressed in
	ventricular zone; ; right kidney; ; neural layer of retina; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; neural tube; ; lip; ; granulocyte; ; ganglionic eminence; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	pre-mRNA intronic pyrimidine-rich binding; pre-mRNA intronic binding; miRNA binding; zinc ion binding; metal ion binding; mRNA 3'-UTR binding; protein binding; RNA binding; nucleic acid binding; mRNA binding; cyclin binding;
Cellular component	cytoplasm; nuclear speck; nucleoplasm; nucleolus; cytoplasmic stress granule; nucleus; cytosol;
Biological process	cell differentiation; regulation of nucleocytoplasmic transport; RNA processing; negative regulation of translation; negative regulation of translation in response to stress; negative regulation of translational initiation; positive regulation of muscle cell differentiation; mRNA processing; response to arsenic-containing substance; regulation of alternative mRNA splicing, via spliceosome; cap-independent translational initiation; circadian regulation of translation; miRNA-mediated gene silencing by inhibition of translation; IRES-dependent translational initiation of linear mRNA; RNA splicing; gene silencing; entrainment of circadian clock by photoperiod; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	5936
	19653
	ENSG00000173933
	ENSMUSG00000094936
	Q9BWF3
	Q8C7Q4
	NM_002896; NM_001198843; NM_001198844
	NM_001290122; NM_001290123; NM_001290124; NM_001290125; NM_009032
	NP_001185772; NP_001185773; NP_002887
	NP_001277051; NP_001277052; NP_001277053; NP_001277054; NP_033058
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 4 is a protein that in humans is encoded by the RBM4 gene.

RBM4 is a protein categorized as an RNA recognition motif (RRM). RRM proteins represent a substantial and functionally varied category of RNA-binding proteins, participating in various functions such as RNA processing and transport, the control of RNA stability, and translational regulation. The RBM4 protein also can be recognized as Lark. Over the past five years, data has emerged from investigations involving mammalian cells, providing a clearer understanding of RBM4's functions. It is now evident that RBM4 serves as an RNA-binding protein, participating in a wide array of cellular processes, which encompass the alternative splicing of pre-mRNA, translation control, and RNA silencing. Structurally, RBM4 shares similarities with other RNA-binding proteins, featuring two RNA recognition motifs and a CCHC-type zinc finger. Notably, RBM4 demonstrates a high degree of conservation throughout the process of evolution. In the context of the human RBM4 gene, it shares an impressive 95% similarity with its murine counterpart.