RNA-binding protein 8A

RBM8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA binding motif protein 8A
External IDs	OMIM: 605313; MGI: 1913129; HomoloGene: 3744; GeneCards: RBM8A; OMA:RBM8A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,927,678 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,541,107 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; gastrocnemius muscle; ; islet of Langerhans; ; skin of abdomen; ; monocyte; ; right testis; ; left testis;
	Top expressed in
	embryo; ; embryo; ; interventricular septum; ; ventricular zone; ; blastocyst; ; yolk sac; ; morula; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; mRNA binding;
Cellular component	cytosol; catalytic step 2 spliceosome; exon-exon junction complex; soma; dendrite; spliceosomal complex; nucleus; cytoplasm; nucleoplasm; nuclear speck; U2-type catalytic step 1 spliceosome;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; RNA processing; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA 3'-end processing; regulation of translation; RNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA splicing; transport;
	Sources:Amigo / QuickGO
Orthologs
	9939
	60365
	ENSG00000265241
	ENSMUSG00000038374
	Q9Y5S9
	Q9CWZ3
	NM_005105
	NM_001102407; NM_025875
	NP_005096
	NP_001095877; NP_080151
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.