RBPJ

RBPJ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F8X, 3NBN, 3V79
Identifiers
Aliases	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
External IDs	OMIM: 147183; MGI: 96522; HomoloGene: 7511; GeneCards: RBPJ; OMA:RBPJ - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	26,435,131 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,814,704 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; Achilles tendon; ; nipple; ; corpus callosum; ; dorsal motor nucleus of vagus nerve; ; middle temporal gyrus; ; synovial joint; ; inferior ganglion of vagus nerve; ; pericardium; ; visceral pleura;
	Top expressed in
	vestibular membrane of cochlear duct; ; stroma of bone marrow; ; ventricular zone; ; zygote; ; renal corpuscle; ; carotid body; ; ciliary body; ; Paneth cell; ; medial ganglionic eminence; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; protein binding; DNA strand exchange activity; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription factor activity; sequence-specific DNA binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleolus; MAML1-RBP-Jkappa- ICN1 complex; transcription regulator complex; cytoplasm; nucleus; nucleoplasm; transcription repressor complex;
Biological process	artery morphogenesis; regulation of transcription by RNA polymerase II; neuron differentiation; epidermal cell fate specification; positive regulation of cell population proliferation; club cell differentiation; somatic stem cell population maintenance; endocardium development; cell fate commitment; DNA recombination; somitogenesis; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; defense response to bacterium; regulation of timing of cell differentiation; regulation of transcription, DNA-templated; humoral immune response; keratinocyte differentiation; hair follicle maturation; negative regulation of cell population proliferation; pituitary gland development; negative regulation of cell differentiation; Notch signaling involved in heart development; transcription, DNA-templated; positive regulation of gene expression; arterial endothelial cell fate commitment; myeloid dendritic cell differentiation; blood vessel remodeling; secondary heart field specification; regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; sebaceous gland development; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; inflammatory response to antigenic stimulus; heart development; auditory receptor cell fate commitment; B cell differentiation; regulation of gene expression; Notch signaling pathway; dorsal aorta morphogenesis; atrioventricular canal development; positive regulation of ephrin receptor signaling pathway; epithelial to mesenchymal transition involved in endocardial cushion formation; outflow tract morphogenesis; cardiac left ventricle morphogenesis; negative regulation of transcription by RNA polymerase II; labyrinthine layer blood vessel development; blood vessel lumenization; endocardium morphogenesis; ventricular trabecula myocardium morphogenesis; negative regulation of ossification; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of cardiac muscle cell proliferation; angiogenesis; epithelial to mesenchymal transition; positive regulation of BMP signaling pathway; positive regulation of ERBB signaling pathway; blood vessel endothelial cell fate specification; negative regulation of transcription, DNA-templated; positive regulation of transcription of Notch receptor target; positive regulation of Notch signaling pathway; hemopoiesis; aortic valve development; pulmonary valve development; ventricular septum morphogenesis; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3516
	19664
	ENSG00000168214
	ENSMUSG00000039191
	Q06330
	P31266
NM_005349; NM_015874; NM_203283; NM_203284; NM_001363577;
	NM_001374400; NM_001374401; NM_001374402; NM_001374403; NM_001379406; NM_001379407; NM_001379408; NM_001379409
	NM_001080927; NM_001080928; NM_001277116; NM_009035; NM_001359152
NP_005340; NP_056958; NP_976028; NP_976029; NP_001350506;
	NP_001361329; NP_001361330; NP_001361331; NP_001361332; NP_001366335; NP_001366336; NP_001366337; NP_001366338
	NP_001074396; NP_001074397; NP_001264045; NP_033061; NP_001346081
	Wikidata
View/Edit Human	View/Edit Mouse

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.

RBPJ also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.