RDH12

RDH12
Identifiers
Aliases	RDH12, LCA13, LCA3, RP53, SDR7C2, retinol dehydrogenase 12 (all-trans/9-cis/11-cis), retinol dehydrogenase 12
External IDs	OMIM: 608830; MGI: 1925224; HomoloGene: 110830; GeneCards: RDH12; OMA:RDH12 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,734,451 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	79,269,439 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of leg; ; vulva; ; skin of abdomen; ; skin of thigh; ; gums; ; gingival epithelium; ; gallbladder; ; human penis; ; skin of hip;
	Top expressed in
	neural layer of retina; ; granulocyte; ; esophagus; ; retinal pigment epithelium; ; lip; ; epithelium of lens; ; skin of external ear; ; secondary oocyte; ; skin of abdomen; ; skin of back;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NAD-retinol dehydrogenase activity; oxidoreductase activity; protein binding; NADP-retinol dehydrogenase activity;
Cellular component	intracellular anatomical structure; photoreceptor inner segment membrane; photoreceptor inner segment; endoplasmic reticulum; endoplasmic reticulum membrane; membrane;
Biological process	photoreceptor cell maintenance; visual perception; retinoid metabolic process; retinol metabolic process; response to stimulus; cellular detoxification of aldehyde;
	Sources:Amigo / QuickGO
Orthologs
	145226
	77974
	ENSG00000139988
	ENSMUSG00000021123
	Q96NR8
	Q8BYK4
	NM_152443
	NM_030017; NM_001313971
	NP_689656
	NP_001300900; NP_084293
	Wikidata
View/Edit Human	View/Edit Mouse

Retinol dehydrogenase 12 is an enzyme that in humans is encoded by the RDH12 gene.

Retinoids are indispensable light-sensitive elements of vision and also serve as essential modulators of cellular differentiation and proliferation in diverse cell types. RDH12 belongs to a family of dual-specificity retinol dehydrogenases that metabolize both all-trans- and cis-retinols (Haeseleer et al., 2002).[supplied by OMIM]