REG3A

REG3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UV0, 2GO0, 4MTH
Identifiers
Aliases	REG3A, HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3, regenerating family member 3 alpha
External IDs	OMIM: 167805; MGI: 97478; HomoloGene: 130506; GeneCards: REG3A; OMA:REG3A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	79,159,753 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	78,350,449 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; duodenum; ; body of pancreas; ; pancreatic ductal cell; ; islet of Langerhans; ; beta cell; ; testicle; ; pylorus; ; gallbladder;
	Top expressed in
	Paneth cell; ; jejunum; ; duodenum; ; crypt of lieberkuhn of small intestine; ; intestinal villus; ; ileum; ; Ileal epithelium; ; pyloric antrum; ; islet of Langerhans; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; identical protein binding; transmembrane signaling receptor activity; peptidoglycan binding; oligosaccharide binding;
Cellular component	cytoplasm; extracellular region; extracellular space;
Biological process	inflammatory response; multicellular organism development; negative regulation of keratinocyte differentiation; positive regulation of keratinocyte proliferation; cell population proliferation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of wound healing; acute-phase response; antimicrobial humoral response; positive regulation of cell population proliferation; response to peptide hormone; cell wall disruption in other organism; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	5068
	18489
	ENSG00000172016
	ENSMUSG00000071356
	Q06141
	P35230
	NM_138938; NM_002580; NM_138937
	NM_011036
	NP_002571; NP_620354; NP_620355
	NP_035166
	Wikidata
View/Edit Human	View/Edit Mouse

Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23 is a protein that in humans is encoded by the REG3A gene.

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.

Reg3A (UniProt Q0614 1) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan and executed by the formation of a hexameric pore in the membrane.