REG3G

REG3G
Identifiers
Aliases	REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma
External IDs	OMIM: 609933; MGI: 109406; HomoloGene: 128216; GeneCards: REG3G; OMA:REG3G - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	79,028,505 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	78,445,855 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; right testis; ; left testis; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; pancreatic ductal cell; ; mucosa of ileum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; respiratory epithelium; ; nasal epithelium; ; olfactory epithelium; ; superior surface of tongue; ; duodenum; ; intestinal villus; ; Paneth cell; ; jejunum; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; peptidoglycan binding; oligosaccharide binding; transmembrane signaling receptor activity;
Cellular component	cytoplasm; extracellular region; extracellular space;
Biological process	positive regulation of wound healing; positive regulation of keratinocyte proliferation; negative regulation of keratinocyte differentiation; inflammatory response; acute-phase response; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; response to peptide hormone; cell wall disruption in other organism;
	Sources:Amigo / QuickGO
Orthologs
	130120
	19695
	ENSG00000143954
	ENSMUSG00000030017
	Q6UW15
	O09049
	NM_001008387; NM_001270040; NM_198448
	NM_011260
	NP_001008388; NP_001256969; NP_940850
	NP_035390
	Wikidata
View/Edit Human	View/Edit Mouse

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.