REL

REL
Identifiers
Aliases	REL, C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92
External IDs	OMIM: 164910; MGI: 97897; HomoloGene: 2182; GeneCards: REL; OMA:REL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	60,931,612 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,720,970 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; bone marrow; ; secondary oocyte; ; bone marrow cells; ; monocyte; ; epithelium of colon; ; mucosa of urinary bladder; ; human penis; ; cartilage tissue; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; spleen; ; granulocyte; ; conjunctival fornix; ; skin of external ear; ; bone marrow; ; secondary oocyte; ; cumulus cell; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; cytosol; I-kappaB/NF-kappaB complex; transcription regulator complex; nucleoplasm; nucleus;
Biological process	response to cytokine; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of interferon-beta production; negative regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; NIK/NF-kappaB signaling; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; inflammatory response; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; I-kappaB kinase/NF-kappaB signaling; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5966
	19696
	ENSG00000162924
	ENSMUSG00000020275
	Q04864
	P15307
	NM_001291746; NM_002908
	NM_009044
	NP_001278675; NP_002899
	NP_033070
	Wikidata
View/Edit Human	View/Edit Mouse

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.