RE1-silencing transcription factor

REST
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CZY
Identifiers
Aliases	REST, Rest, 2610008J04Rik, AA407358, NRSF, XBR, REST4, WT6, RE1 silencing transcription factor, GINGF5, HGF5, DFNA27
External IDs	OMIM: 600571; MGI: 104897; HomoloGene: 4099; GeneCards: REST; OMA:REST - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	56,966,808 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,434,279 bp
RNA expression pattern
	Top expressed in
	gonad; ; mucosa of paranasal sinus; ; testicle; ; Achilles tendon; ; epithelium of nasopharynx; ; epithelium of colon; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; bone marrow cells; ; oral cavity;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; zygote; ; superior surface of tongue; ; cumulus cell; ; gallbladder; ; human fetus; ; secondary oocyte; ; primary oocyte; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; outward rectifier potassium channel activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; metal ion binding; core promoter sequence-specific DNA binding; protein binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase activity; chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	cytosol; nucleoplasm; transcription repressor complex; nucleus; cytoplasm; histone methyltransferase complex;
Biological process	cellular response to electrical stimulus; negative regulation of dense core granule biogenesis; negative regulation of insulin secretion; negative regulation of cortisol biosynthetic process; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of gene expression; transcription, DNA-templated; negative regulation of amniotic stem cell differentiation; positive regulation of transcription, DNA-templated; negative regulation of mesenchymal stem cell differentiation; histone H4 deacetylation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to glucocorticoid stimulus; negative regulation of calcium ion-dependent exocytosis; hematopoietic progenitor cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-templated; cardiac muscle cell myoblast differentiation; negative regulation of neurogenesis; potassium ion transmembrane transport; regulation of transcription, DNA-templated; positive regulation of apoptotic process; negative regulation of neuron differentiation; regulation of transcription by RNA polymerase II; regulation of alternative mRNA splicing, via spliceosome; response to hypoxia; regulation of gene expression; positive regulation of neuron differentiation; regulation of osteoblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5978
	19712
	ENSG00000084093
	ENSMUSG00000029249
	Q13127
	Q8VIG1
	NM_001193508; NM_005612; NM_001363453
	NM_011263
	NP_001180437; NP_005603; NP_001350382
	NP_035393
	Wikidata
View/Edit Human	View/Edit Mouse

RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. REST is expressly involved in the repression of neural genes in non-neuronal cells. Many genetic disorders have been tied to alterations in the REST expression pattern, including colon and small-cell lung carcinomas found with truncated versions of REST. In addition to these cancers, defects in REST have also been attributed a role in Huntington Disease, neuroblastomas, and the effects of epileptic seizures and ischemia.