RFFL

RFFL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Y02

Identifiers

RFFL, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase, ring finger and FYVE like domain containing E3 ubiquitin protein ligase

External IDs

OMIM: 609735; MGI: 1914588; HomoloGene: 12116; GeneCards: RFFL; OMA:RFFL - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q12	Start	35,005,990 bp
Band	17q12	End	35,089,319 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 C	Start	82,693,275 bp
Band	11\|11 C	End	82,762,036 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

inferior ganglion of vagus nerve

secondary oocyte

pancreatic epithelial cell

buccal mucosa cell

corpus callosum

mucosa of ileum

spinal cord

amniotic fluid

subthalamic nucleus

C1 segment

Top expressed in

granulocyte

olfactory epithelium

zygote

secondary oocyte

lacrimal gland

seminiferous tubule

spermatid

blood

epithelium of stomach

primary oocyte

More reference expression data

n/a

Gene ontology
Molecular function	p53 binding metal ion binding protease binding protein binding protein kinase binding ubiquitin protein ligase binding ubiquitin protein ligase activity transferase activity
Cellular component	cytoplasm cytosol endosome membrane plasma membrane Golgi membrane tumor necrosis factor receptor superfamily complex recycling endosome membrane lysosome endosome membrane nucleoplasm
Biological process	regulation of TOR signaling ubiquitin-dependent protein catabolic process negative regulation of tumor necrosis factor-mediated signaling pathway protein K48-linked ubiquitination negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein ubiquitination negative regulation of signal transduction by p53 class mediator regulation of fibroblast migration proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process
Sources:Amigo / QuickGO

Species

Human

Mouse


117584


67338


ENSG00000092871


ENSMUSG00000020696


Q8WZ73


Q6ZQM0

RefSeq (mRNA)


NM_001017368 NM_057178


NM_001007465 NM_001164569 NM_001164570 NM_001164571 NM_026097

RefSeq (protein)


NP_001017368


NP_001007466 NP_001158041 NP_001158042 NP_001158043 NP_080373

Location (UCSC)

Chr 17: 35.01 – 35.09 Mb

Chr 11: 82.69 – 82.76 Mb

PubMed search

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase RFFL (Ring Finger And FYVE Like Domain Containing E3 Ubiquitin) is a ubiquitin ligase enzyme that in humans is encoded by the RFFL gene. RFFL associates with endosomes. RFFL is known to affect cardiac repolarization, Cystic fibrosis transmembrane conductance regulator (CFTR) ubiquitination, and mitochondrial clearance by affecting Parkin/PRKN recruitment.