Regucalcin

RGN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3G4E, 3G4H, 4GNB, 4GNC
Identifiers
Aliases	RGN, GNL, HEL-S-41, RC, SMP30, regucalcin
External IDs	OMIM: 300212; MGI: 108024; HomoloGene: 3437; GeneCards: RGN; OMA:RGN - orthologs
EC number	3.1.1.17
Gene location (Human)
Chr.	X chromosome (human)
End	47,093,314 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,428,328 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; kidney tubule; ; human kidney; ; body of pancreas; ; jejunal mucosa; ; right lung; ; cerebellar hemisphere;
	Top expressed in
	left lobe of liver; ; gallbladder; ; primary oocyte; ; migratory enteric neural crest cell; ; fetal liver hematopoietic progenitor cell; ; zygote; ; secondary oocyte; ; human fetus; ; sexually immature organism; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; gluconolactonase activity; zinc ion binding; enzyme regulator activity; metal ion binding; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleus; extracellular region;
Biological process	negative regulation of protein phosphorylation; positive regulation of triglyceride biosynthetic process; positive regulation of ATP-dependent activity; negative regulation of protein kinase activity; kidney development; negative regulation of flagellated sperm motility; ageing; positive regulation of proteolysis involved in cellular protein catabolic process; cellular calcium ion homeostasis; negative regulation of apoptotic process; positive regulation of glucose metabolic process; positive regulation of fatty acid biosynthetic process; negative regulation of bone development; positive regulation of dUTP diphosphatase activity; positive regulation of phosphatase activity; positive regulation of GTPase activity; liver regeneration; negative regulation of GTPase activity; negative regulation of nitric oxide biosynthetic process; negative regulation of RNA biosynthetic process; spermatogenesis; regulation of calcium-mediated signaling; negative regulation of epithelial cell proliferation; negative regulation of leucine-tRNA ligase activity; negative regulation of phosphoprotein phosphatase activity; liver development; negative regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of DNA catabolic process; negative regulation of DNA biosynthetic process; positive regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of calcium-dependent ATPase activity; positive regulation of superoxide dismutase activity; L-ascorbic acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9104
	19733
	ENSG00000130988
	ENSMUSG00000023070
	Q15493
	Q64374
	NM_001282848; NM_001282849; NM_004683; NM_152869
	NM_009060
	NP_001269777; NP_001269778; NP_004674; NP_690608
	NP_033086
	Wikidata
View/Edit Human	View/Edit Mouse

Regucalcin is a protein that in humans is encoded by the RGN gene

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver, kidney and other tissues. It may have an important role in calcium homeostasis. Studies in rats indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.

Regucalcin is a proposed name for a calcium-binding protein that was discovered in 1978 This protein is also known as Senescence Marker Protein-30 (SMP30). Regucalcin differs from calmodulin and other Ca²⁺-related proteins as it does not contain an EF-hand motif of Ca²⁺-binding domain. It may regulate the effect of Ca²⁺ on liver cell functions. From many investigations, regucalcin has been shown to play a multifunctional role in many cell types as a regulatory protein in the intracellular signaling system.