RGPD5

RGPD5
Identifiers
Aliases	RGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDs	OMIM: 612708; MGI: 894323; HomoloGene: 87808; GeneCards: RGPD5; OMA:RGPD5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	109,857,705 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	58,330,178 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; buccal mucosa cell; ; sural nerve; ; trachea; ; testicle; ; nipple; ; pylorus; ; muscle of thigh; ; bone marrow cells; ; superior surface of tongue;
	Top expressed in
	human fetus; ; Gonadal ridge; ; lobe of cerebellum; ; lacrimal gland; ; cerebellar vermis; ; spermatocyte; ; spermatid; ; left lung lobe; ; primitive streak; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	cytoplasm; nucleus; nuclear pore; centrosome;
Biological process	intracellular transport; NLS-bearing protein import into nucleus; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	84220
	19386
	ENSG00000015568
	ENSMUSG00000003226
	Q99666
	Q9ERU9
	NM_005054; NM_032260
	NM_011240
	NP_005045; NP_115636
	NP_035370
	Wikidata
View/Edit Human	View/Edit Mouse

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.