RGS1

RGS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BV1, 2GTP
Identifiers
Aliases	RGS1, 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, regulator of G protein signaling 1
External IDs	OMIM: 600323; MGI: 1354694; HomoloGene: 2191; GeneCards: RGS1; OMA:RGS1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	192,580,024 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	144,124,980 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; olfactory bulb; ; right lung; ; rectum; ; appendix; ; tibial nerve; ; gallbladder; ; lymph node; ; epithelium of nasopharynx; ; right uterine tube;
	Top expressed in
	stroma of bone marrow; ; mesenteric lymph nodes; ; granulocyte; ; spleen; ; duodenum; ; large intestine; ; colon; ; jejunum; ; pyloric antrum; ; decidua;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G-protein alpha-subunit binding; GTPase activator activity; calmodulin binding; GTPase activity;
Cellular component	extrinsic component of cytoplasmic side of plasma membrane; cytosol; plasma membrane; membrane; cytoplasm;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; negative regulation of signal transduction; leukotriene signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; immune response; regulation of G protein-coupled receptor signaling pathway; signal transduction; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	5996
	50778
	ENSG00000090104
	ENSMUSG00000026358
	Q08116
	Q9JL25
	NM_002922
	NM_015811
	NP_002913
	NP_056626
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.