RGS11

RGS11
Identifiers
Aliases	RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895; MGI: 1354739; HomoloGene: 77719; GeneCards: RGS11; OMA:RGS11 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	275,980 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,430,298 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; C1 segment; ; cingulate gyrus; ; anterior cingulate cortex; ; tibial nerve; ; Amygdala; ; Brodmann area 9; ; apex of heart;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; morula; ; primary visual cortex; ; islet of Langerhans; ; adrenal gland; ; ganglion of vagus nerve; ; autonomic nerve plexus; ; CA3 field; ; stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G-protein beta-subunit binding; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; plasma membrane; protein-containing complex; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of signal transduction; intracellular signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	8786
	50782
	ENSG00000076344
	ENSMUSG00000024186
	O94810
	Q9Z2H1
	NM_001286485; NM_001286486; NM_003834; NM_183337
	NM_001081069
	NP_001273414; NP_001273415; NP_003825; NP_899180
	NP_001074538
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.