RGS12

RGS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBZ, 2KV8
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,439,913 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,196,988 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; mucosa of esophagus; ; skin of leg; ; right uterine tube; ; skin of abdomen; ; right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; ectocervix;
	Top expressed in
	spermatocyte; ; lip; ; hand; ; ventricular zone; ; genital tubercle; ; Rostral migratory stream; ; spermatid; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase regulator activity; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; cell projection; nuclear matrix; synapse; condensed nuclear chromosome; cell junction; dendrite; plasma membrane; nucleus; nucleolus; cytosol;
Biological process	regulation of G protein-coupled receptor signaling pathway; transcription, DNA-templated; positive regulation of GTPase activity; negative regulation of signal transduction; signal transduction; regulation of catalytic activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6002
	71729
	ENSG00000159788
	ENSMUSG00000029101
	O14924
	Q8CGE9
NM_002926; NM_198227; NM_198229; NM_198230; NM_198430;
	NM_198432; NM_198587; NM_001394154; NM_001394155; NM_001394156; NM_001394157; NM_001394158; NM_001394159; NM_001394161; NM_001394162; NM_001394163
	NM_001163512; NM_173402
	NP_002917; NP_937870; NP_937872
NP_001156984; NP_775578; NP_001390400; NP_001390401; NP_001390402;
	NP_001390403; NP_001390404; NP_001390405; NP_001390406; NP_001390407
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.