RGS2

RGS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AF0, 2V4Z, 4EKC, 4EKD
Identifiers
Aliases	RGS2, G0S8, regulator of G-protein signaling 2, regulator of G protein signaling 2
External IDs	OMIM: 600861; MGI: 1098271; HomoloGene: 2192; GeneCards: RGS2; OMA:RGS2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	192,812,275 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,879,899 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; periodontal fiber; ; monocyte; ; tail of epididymis; ; gastric mucosa; ; granulocyte; ; seminal vesicula; ; mucosa of urinary bladder; ; bone marrow; ; jejunal mucosa;
	Top expressed in
	cumulus cell; ; gastrula; ; zygote; ; secondary oocyte; ; primary oocyte; ; median eminence; ; left lung lobe; ; dorsal striatum; ; nucleus accumbens; ; lobe of prostate;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; calmodulin binding; protein binding; G-protein alpha-subunit binding; beta-tubulin binding; GTPase activity;
Cellular component	membrane; nucleolus; mitochondrion; neuron projection; cytoplasmic side of plasma membrane; nucleus; cytoplasm; plasma membrane; cytosol;
Biological process	negative regulation of cAMP-mediated signaling; regulation of G protein-coupled receptor signaling pathway; negative regulation of cardiac muscle hypertrophy; positive regulation of GTPase activity; negative regulation of MAP kinase activity; positive regulation of cardiac muscle contraction; spermatogenesis; brown fat cell differentiation; positive regulation of microtubule polymerization; relaxation of vascular associated smooth muscle; cell cycle; negative regulation of signal transduction; negative regulation of G protein-coupled receptor signaling pathway; relaxation of cardiac muscle; regulation of translation; negative regulation of phospholipase activity; negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process; response to amphetamine; brain development; positive regulation of neuron projection development; negative regulation of translation; ovulation; response to ethanol; maternal process involved in female pregnancy; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of glycine import across plasma membrane; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5997
	19735
	ENSG00000116741
	ENSMUSG00000026360
	P41220
	O08849
	NM_002923
	NM_009061
	NP_002914; NP_002914.1
	NP_033087
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).