RGS5

RGS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRP
Identifiers
Aliases	RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDs	OMIM: 603276; MGI: 1098434; HomoloGene: 2682; GeneCards: RGS5; OMA:RGS5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	163,321,791 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	169,523,382 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; cardia; ; urethra; ; pylorus; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; visceral pleura; ; seminal vesicula; ; right ventricle;
	Top expressed in
	tunica media of zone of aorta; ; transitional epithelium of urinary bladder; ; body of femur; ; ankle; ; olfactory epithelium; ; digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; GTPase activity;
Cellular component	plasma membrane; membrane; cytoplasm; cytosol;
Biological process	negative regulation of signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8490
	19737
	ENSG00000143248
	ENSMUSG00000026678
	O15539
	O08850
	NM_001195303; NM_001254748; NM_001254749; NM_003617; NM_025226
	NM_009063; NM_001313705
	NP_001182232; NP_001241677; NP_001241678; NP_003608; NP_003608.1
	NP_001300634; NP_033089
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.