RGS7

RGS7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A72, 2D9J
Identifiers
Aliases	RGS7, regulator of G protein signaling 7
External IDs	OMIM: 602517; MGI: 1346089; HomoloGene: 2193; GeneCards: RGS7; OMA:RGS7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	241,357,374 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	175,320,066 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; frontal pole; ; Region I of hippocampus proper; ; orbitofrontal cortex; ; Brodmann area 46; ; Brodmann area 10; ; primary visual cortex; ; paraflocculus of cerebellum;
	Top expressed in
	facial motor nucleus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; Cortex of frontal lobe; ; superior frontal gyrus; ; prefrontal cortex; ; temporal lobe; ; primary motor cortex; ; cingulate gyrus; ; Amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G-protein beta-subunit binding; GTPase activator activity; GTPase activity;
Cellular component	cytosol; membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; negative regulation of signal transduction; intracellular signal transduction; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	6000
	24012
	ENSG00000182901
	ENSMUSG00000026527
	P49802
	O54829
NM_001282773; NM_001282775; NM_001282778; NM_002924; NM_001350113;
	NM_001350114; NM_001350115; NM_001350116; NM_001364886; NM_001374806; NM_001374807; NM_001374808; NM_001374809; NM_001374810; NM_001374811; NM_001374812; NM_001374813; NM_001374814; NM_001374815; NM_001374816
	NM_001199003; NM_011880; NM_001347195; NM_001357129
NP_001269702; NP_001269704; NP_001269707; NP_002915; NP_001337042;
	NP_001337043; NP_001337044; NP_001337045; NP_001351815; NP_001361735; NP_001361736; NP_001361737; NP_001361738; NP_001361739; NP_001361740; NP_001361741; NP_001361742; NP_001361743; NP_001361744; NP_001361745
	NP_001185932; NP_001334124; NP_036010; NP_001344058
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.