RGS8

RGS8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IHD, 2ODE, 5DO9
Identifiers
Aliases	RGS8, regulator of G protein signaling 8
External IDs	OMIM: 607189; MGI: 108408; HomoloGene: 23152; GeneCards: RGS8; OMA:RGS8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	182,684,587 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	153,576,069 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; nucleus accumbens; ; Pons; ; putamen; ; caudate nucleus; ; cerebellar vermis; ; testicle; ; gonad; ; sperm; ; pars reticulata;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; neural layer of retina; ; medial geniculate nucleus; ; medial dorsal nucleus; ; superior colliculus; ; lateral geniculate nucleus; ; olfactory tubercle; ; inferior colliculi; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; neuronal cell body membrane; perikaryon; plasma membrane; dendrite; cell projection; membrane; nucleus;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; regulation of dopamine receptor signaling pathway; positive regulation of GTPase activity; negative regulation of signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	85397
	67792
	ENSG00000135824
	ENSMUSG00000042671
	P57771
	Q8BXT1
NM_001102450; NM_033345; NM_001369564; NM_001387847; NM_001387848;
	NM_001387849
	NM_026380; NM_001347115; NM_001357525
	NP_001095920; NP_203131; NP_001356493
	NP_001334044; NP_080656; NP_001344454
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.