RHBDF1

RHBDF1
Identifiers
Aliases	RHBDF1, C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1, rhomboid 5 homolog 1
External IDs	OMIM: 614403; MGI: 104328; HomoloGene: 32085; GeneCards: RHBDF1; OMA:RHBDF1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	76,355 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,172,300 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; tibial arteries; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; Descending thoracic aorta; ; canal of the cervix; ; right lung; ; gastric mucosa; ; sural nerve;
	Top expressed in
	interventricular septum; ; external carotid artery; ; internal carotid artery; ; primary oocyte; ; ankle; ; lip; ; esophagus; ; medullary collecting duct; ; carotid body; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine-type endopeptidase activity; growth factor binding; protein binding;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	protein transport; regulation of proteasomal protein catabolic process; protein processing; regulation of epidermal growth factor receptor signaling pathway; cell population proliferation; cell migration; negative regulation of protein secretion; proteolysis; regulation of protein secretion;
	Sources:Amigo / QuickGO
Orthologs
	64285
	13650
	ENSG00000007384
	ENSMUSG00000020282
	Q96CC6
	Q6PIX5
	NM_022450
	NM_001291818; NM_010117
	NP_071895
	NP_001278747; NP_034247
	Wikidata
View/Edit Human	View/Edit Mouse

Inactive rhomboid protein 1 (iRhom1) also known as rhomboid 5 homolog 1 or rhomboid family member 1 (RHBDF1) is a protein that in humans is encoded by the RHBDF1 gene. The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.