RHOBTB1

RHOBTB1
Identifiers
Aliases	RHOBTB1, Rho related BTB domain containing 1
External IDs	OMIM: 607351; MGI: 1916538; HomoloGene: 8892; GeneCards: RHOBTB1; OMA:RHOBTB1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	61,001,440 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	69,127,621 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; muscle of thigh; ; biceps brachii; ; right uterine tube; ; placenta; ; Skeletal muscle tissue of biceps brachii; ; cardia; ; glutes;
	Top expressed in
	myocardium of ventricle; ; internal carotid artery; ; cumulus cell; ; aortic valve; ; ascending aorta; ; external carotid artery; ; ureter; ; islet of Langerhans; ; otolith organ; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity; protein kinase binding;
Cellular component	cytosol; plasma membrane; intracellular anatomical structure; cytoplasm; cytoskeleton; cell projection;
Biological process	regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; cell morphogenesis; actin filament organization; Rho protein signal transduction; cell migration; actin cytoskeleton organization; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologs
	9886
	69288
	ENSG00000072422
	ENSMUSG00000019944
	O94844
	Q9DAK3
NM_001242359; NM_014836; NM_001350902; NM_001350903; NM_001350904;
	NM_001350905; NM_001350906; NM_001350907; NM_001350908; NM_001350909; NM_001350910; NM_001350911
	NM_001081347; NM_001252636; NM_001252637; NM_001252638
NP_001229288; NP_055651; NP_001337831; NP_001337832; NP_001337833;
	NP_001337834; NP_001337835; NP_001337836; NP_001337837; NP_001337838; NP_001337839; NP_001337840; NP_001229288.1; NP_055651.1
	NP_001074816; NP_001239565; NP_001239566; NP_001239567
	Wikidata
View/Edit Human	View/Edit Mouse

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.

The protein encoded by this gene belongs to the Rho family, which is part of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, two tandem BTB (broad complex, tramtrack, and bric-à-brac) domains, and a conserved C-terminal region. This protein plays a role in small GTPase-mediated signal transduction and in the organization of the actin filament system. Alternative transcriptional splice variants of this gene have been characterized.