RhoD

RHOD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J1L
Identifiers
Aliases	RHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDs	OMIM: 605781; MGI: 108446; HomoloGene: 22409; GeneCards: RHOD; OMA:RHOD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,072,017 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,489,460 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right lobe of liver; ; apex of heart; ; skin of leg; ; skin of abdomen; ; gums; ; gingival epithelium; ; left ventricle; ; skin of thigh; ; amniotic fluid;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; lip; ; esophagus; ; corneal stroma; ; choroid plexus of fourth ventricle; ; right kidney; ; jejunum; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase binding; GTP binding; GTPase activity;
Cellular component	early endosome; endosome membrane; endosome; membrane; cytosol; plasma membrane; intracellular anatomical structure; cytoplasm; cell cortex; cell division site; intracellular membrane-bounded organelle;
Biological process	positive regulation of cell adhesion; focal adhesion assembly; actin filament bundle assembly; regulation of actin cytoskeleton reorganization; positive regulation of cell migration; lamellipodium assembly; Rho protein signal transduction; regulation of focal adhesion assembly; protein targeting; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; actin filament organization; regulation of cell shape; cell migration; regulation of cell migration; establishment or maintenance of actin cytoskeleton polarity; regulation of actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	29984
	11854
	ENSG00000173156
	ENSMUSG00000041845
	O00212
	P97348
	NM_014578; NM_001300886
	NM_007485; NM_001329989
	NP_001287815; NP_055393
	NP_001316918; NP_031511
	Wikidata
View/Edit Human	View/Edit Mouse

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD.

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.