RHOQ

RHOQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ATX
Identifiers
Aliases	RHOQ, ARHQ, HEL-S-42, RASL7A, TC10, TC10A, ras homolog family member Q
External IDs	OMIM: 605857; MGI: 1931553; HomoloGene: 22704; GeneCards: RHOQ; OMA:RHOQ - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,584,688 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,307,497 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; Achilles tendon; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; thoracic diaphragm; ; cardiac muscle tissue of right atrium; ; Epithelium of choroid plexus; ; muscle of thigh;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; ankle; ; digastric muscle; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GBD domain binding; profilin binding; nucleotide binding; GTP binding; GTPase activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; actin filament; membrane raft; Golgi-associated vesicle membrane; extracellular exosome; intracellular anatomical structure; cell cortex; cell projection;
Biological process	positive regulation of glucose import; insulin receptor signaling pathway; regulation of actin cytoskeleton organization; regulation of cell shape; cellular response to insulin stimulus; regulation of small GTPase mediated signal transduction; cortical actin cytoskeleton organization; positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; GTP metabolic process; small GTPase mediated signal transduction; negative regulation of protein localization to plasma membrane; endocytosis; actin filament organization; establishment or maintenance of cell polarity; Rho protein signal transduction; cell projection assembly; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23433
	104215
	ENSG00000119729
	ENSMUSG00000024143
	P17081
	Q8R527
	NM_012249
	NM_145491
	NP_036381
	NP_663466
	Wikidata
View/Edit Human	View/Edit Mouse

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM]

In melanocytic cells RHOQ gene expression may be regulated by MITF.