RHOT1

RHOT1
Identifiers
Aliases	RHOT1, ARHT1, MIRO-1, MIRO1, ras homolog family member T1
External IDs	OMIM: 613888; MGI: 1926078; HomoloGene: 56803; GeneCards: RHOT1; OMA:RHOT1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,253,374 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,158,733 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; secondary oocyte; ; visceral pleura; ; primary visual cortex; ; palpebral conjunctiva; ; skin of thigh; ; gingival epithelium; ; parietal pleura; ; sperm;
	Top expressed in
	neural layer of retina; ; secondary oocyte; ; primary oocyte; ; spermatocyte; ; spermatid; ; right ventricle; ; zygote; ; seminiferous tubule; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activity; protein binding; calcium ion binding; hydrolase activity; metal ion binding; nucleotide binding; GTP binding; molecular function;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; mitochondrion; integral component of mitochondrial outer membrane; mitochondrial outer membrane;
Biological process	cellular homeostasis; regulation of small GTPase mediated signal transduction; mitochondrial outer membrane permeabilization; mitochondrion organization; protein deubiquitination; establishment of mitochondrion localization by microtubule attachment; regulation of neurotransmitter secretion; regulation of organelle transport along microtubule; mitochondrion transport along microtubule; Rho protein signal transduction; regulation of mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
	55288
	59040
	ENSG00000126858
	ENSMUSG00000017686
	Q8IXI2
	Q8BG51
NM_001033566; NM_001033567; NM_001033568; NM_001288754; NM_001288755;
	NM_001288758; NM_018307
NM_001163354; NM_001163355; NM_021536; NM_001362868; NM_001362869;
	NM_001362870
NP_001028738; NP_001028739; NP_001028740; NP_001275683; NP_001275684;
	NP_001275687; NP_060777
NP_001156826; NP_001156827; NP_067511; NP_001349797; NP_001349798;
	NP_001349799; NP_001391057; NP_001391058
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial Rho GTPase 1 (MIRO1) is an enzyme that in humans is encoded by the RHOT1 gene on chromosome 17. As a Miro protein isoform, the protein facilitates mitochondrial transport by attaching the mitochondria to the motor/adaptor complex. Through its key role in mitochondrial transport, RHOT1 is involved in mitochondrial homeostasis and apoptosis, as well as Parkinson's disease (PD) and cancer.