RHOT2

RHOT2
Identifiers
Aliases	RHOT2, ARHT2, C16orf39, MIRO-2, MIRO2, RASL, ras homolog family member T2
External IDs	OMIM: 613889; MGI: 2384892; HomoloGene: 56038; GeneCards: RHOT2; OMA:RHOT2 - orthologs
RNA expression pattern
	n/a
	n/a
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calcium ion binding; GTP binding; metal ion binding; protein binding; GTPase activity; hydrolase activity;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; integral component of mitochondrial outer membrane; mitochondrial outer membrane; mitochondrion; extracellular exosome;
Biological process	mitochondrion organization; cellular homeostasis; mitochondrion transport along microtubule; regulation of small GTPase mediated signal transduction; mitochondrial outer membrane permeabilization; Rho protein signal transduction; regulation of mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
	89941
	214952
	ENSG00000140983
	n/a
	Q8IXI1
	Q8JZN7
	NM_138769
	NM_145999; NM_001364950
NP_620124; NP_001339204; NP_001339205; NP_001339206; NP_001339207;
	NP_001339209; NP_001339210; NP_001339211; NP_001339212; NP_001339213; NP_001339214; NP_001339215; NP_001339216; NP_001339217; NP_001339218; NP_001339219; NP_001339220; NP_001339221; NP_001339222; NP_001339223; NP_001339208
	NP_666111; NP_001351879
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial Rho GTPase 2 is an enzyme that in humans is encoded by the RHOT2 gene. As a Miro protein isoform, the protein facilitates mitochondrial transport by attaching the mitochondria to the motor/adaptor complex. Through its key role in mitochondrial transport, RHOT2 is involved in mitochondrial homeostasis and apoptosis, as well as Parkinson's disease (PD).