RICS (gene)

ARHGAP32
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IUG
Identifiers
Aliases	ARHGAP32, GC-GAP, GRIT, PX-RICS, RICS, p200RhoGAP, p250GAP, Rho GTPase activating protein 32
External IDs	OMIM: 608541; MGI: 2450166; HomoloGene: 8812; GeneCards: ARHGAP32; OMA:ARHGAP32 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	129,279,324 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	32,179,742 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; secondary oocyte; ; postcentral gyrus; ; endothelial cell; ; Brodmann area 23; ; superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; sural nerve; ; palpebral conjunctiva;
	Top expressed in
	primary motor cortex; ; cingulate gyrus; ; lateral geniculate nucleus; ; olfactory tubercle; ; prefrontal cortex; ; lateral septal nucleus; ; anterior amygdaloid area; ; piriform cortex; ; mammillary body; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylinositol binding; GTPase activator activity; phosphatidylinositol phosphate binding;
Cellular component	cytoplasm; cytosol; endosome; postsynaptic membrane; cell projection; endoplasmic reticulum membrane; membrane; postsynaptic density; Golgi membrane; plasma membrane; dendritic spine; synapse; cell junction; endoplasmic reticulum; endosome membrane; fibrillar center; nucleoplasm; Golgi apparatus; cell cortex; actin cytoskeleton;
Biological process	positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9743
	330914
	ENSG00000134909
	ENSMUSG00000041444
	A7KAX9
	Q811P8
	NM_001142685; NM_014715; NM_001378024; NM_001378025
	NM_001195632; NM_177379; NM_001370957; NM_001370958
	NP_001136157; NP_055530; NP_001364953; NP_001364954
	NP_001182561; NP_796353; NP_001357886; NP_001357887
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi apparatus and endosomes. The only known domain of the RICS is the RhoGAP domain, whilst PX-RICS has an additional Phox homology and SH3 domain.