RICTOR

RICTOR
Identifiers
Aliases	RICTOR, AVO3, PIA, hAVO3, RPTOR independent companion of MTOR complex 2
External IDs	OMIM: 609022; MGI: 1926007; HomoloGene: 34317; GeneCards: RICTOR; OMA:RICTOR - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	39,074,399 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	6,829,882 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; tibialis anterior muscle; ; mucosa of paranasal sinus; ; cardiac muscle tissue of right atrium; ; superficial temporal artery; ; myocardium of left ventricle; ; Brodmann area 23; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; tail of epididymis;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; secondary oocyte; ; Rostral migratory stream; ; zygote; ; inferior colliculi; ; mesenteric lymph nodes; ; habenula; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribosome binding; protein binding; enzyme activator activity; protein kinase binding;
Cellular component	cytosol; TORC2 complex;
Biological process	regulation of protein phosphorylation; actin cytoskeleton reorganization; positive regulation of protein kinase B signaling; positive regulation of endothelial cell proliferation; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization; embryo development; regulation of GTPase activity; regulation of phosphorylation; establishment or maintenance of actin cytoskeleton polarity; multicellular organism development; TOR signaling; peptidyl-serine phosphorylation; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling; establishment of cell polarity; regulation of inflammatory response; positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; regulation of establishment of cell polarity; positive regulation of TOR signaling; activation of protein kinase B activity; embryo development ending in birth or egg hatching; viral process;
	Sources:Amigo / QuickGO
Orthologs
	253260
	78757
	ENSG00000164327
	ENSMUSG00000050310
	Q6R327
	Q6QI06
	NM_001285439; NM_001285440; NM_152756
	NM_030168
	NP_001272368; NP_001272369; NP_689969
	NP_084444
	Wikidata
View/Edit Human	View/Edit Mouse

Rapamycin-insensitive companion of mammalian target of rapamycin (RICTOR) is a protein that in humans is encoded by the RICTOR gene.

RICTOR and mTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.