Telomere-associated protein RIF1

RIF1
Identifiers
Aliases	RIF1, replication timing regulatory factor 1
External IDs	OMIM: 608952; MGI: 1098622; HomoloGene: 41231; GeneCards: RIF1; OMA:RIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	151,508,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	52,012,395 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gastrocnemius muscle; ; muscle of thigh; ; Achilles tendon; ; testicle; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; corpus callosum; ; internal globus pallidus; ; gonad;
	Top expressed in
	spermatocyte; ; zygote; ; secondary oocyte; ; primary oocyte; ; primitive streak; ; cumulus cell; ; epiblast; ; Gonadal ridge; ; spermatid; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; telomere; plasma membrane; spindle; male pronucleus; female pronucleus; nucleus; cytoskeleton; nucleoplasm; chromosome; condensed chromosome; nuclear body; nuclear membrane; spindle midzone; site of double-strand break;
Biological process	stem cell population maintenance; cell cycle; double-strand break repair via nonhomologous end joining; negative regulation of transcription by RNA polymerase II; telomere maintenance; telomere maintenance in response to DNA damage; positive regulation of histone H3-K9 methylation; cellular response to DNA damage stimulus; positive regulation of isotype switching; negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; DNA repair; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	55183
	51869
	ENSG00000080345
	ENSMUSG00000036202
	Q5UIP0
	Q6PR54
	NM_001177663; NM_001177664; NM_001177665; NM_018151
	NM_175238; NM_001355414; NM_001355415
	NP_001171134; NP_001171135; NP_001171136; NP_060621
	NP_780447; NP_001342343; NP_001342344
	Wikidata
View/Edit Human	View/Edit Mouse

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast. In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.