RING finger domain
| Zinc finger, C3HC4 type (RING finger) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the C3HC4 domain. Zinc ions are black spheres, coordinated by cysteines residues (blue). | |||||||||
| Identifiers | |||||||||
| Symbol | zf-C3HC4 | ||||||||
| Pfam | PF00097 | ||||||||
| Pfam clan | CL0229 | ||||||||
| ECOD | 376.1.1 | ||||||||
| InterPro | IPR001841 | ||||||||
| SMART | SM00184 | ||||||||
| PROSITE | PDOC00449 | ||||||||
| SCOP2 | 1chc / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively). This protein domain contains 40 to 60 amino acids. Many proteins containing a RING finger play a key role in the ubiquitination pathway. Conversely, proteins with RING finger domains are the largest type of ubiquitin ligases in the human genome.