Serine/threonine-protein kinase RIO1 is an enzyme that in humans is encoded by the RIOK1 gene.
RIOK1 is an atypical protein, which exists in most archaea and eukaryotes. It belongs to the serine/threonine-specific protein kinase family.
It has been intensely studied to understand the maturation they promote on small ribosomal subunits (SSU). It is suggested that over-expression or mutations of the RIOK 1 gene may cause mis-regulation of its network (in metazoans - large signaling network at the protein and gene levels via which it stimulates or restricts growth and division in response to nutrient availability). This was observed in primary cancer cells and may contribute to cancer initiation and progression.
