RIT2

RIT2
Identifiers
Aliases	RIT2, RIBA, RIN, ROC2, Ras like without CAAX 2
External IDs	OMIM: 609592; MGI: 108054; HomoloGene: 2198; GeneCards: RIT2; OMA:RIT2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	43,115,691 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	31,450,343 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; endothelial cell; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens; ; Hypothalamus; ; right frontal lobe;
	Top expressed in
	ventral tegmental area; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; medial vestibular nucleus; ; habenula; ; suprachiasmatic nucleus; ; central gray substance of midbrain; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; identical protein binding; GTP binding; protein binding; semaphorin receptor binding; chromatin binding; GTPase activity; GDP binding;
Cellular component	membrane; membrane raft; plasma membrane; nucleus; neuron projection; cytoplasm; cell body; dendritic tree;
Biological process	chemical synaptic transmission; signal transduction; MAPK cascade; maintenance of protein location in cell; regulation of endocytosis; intracellular signal transduction; regulation of protein phosphorylation; Ras protein signal transduction; positive regulation of neuron projection development; negative regulation of neuron projection development; regulation of Cdc42 protein signal transduction; positive regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; regulation of calcium-mediated signaling; small GTPase mediated signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6014
	19762
	ENSG00000152214
	ENSMUSG00000057455
	Q99578
	P70425
	NM_002930; NM_001272077
	NM_009065
	NP_001259006; NP_002921
	NP_033091
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]

RIT2 has been associated with Parkinson's disease in two large genetic studies. An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.