Eosinophil-derived neurotoxin

RNASE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GQV, 1HI2, 1HI3, 1HI4, 1HI5, 1K2A, 2BEX, 2BZZ, 2C01, 2C02, 2C05, 5E13
Identifiers
Aliases	RNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2
External IDs	OMIM: 131410; MGI: 1858598; HomoloGene: 121614; GeneCards: RNASE2; OMA:RNASE2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,956,436 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,400,475 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; bone marrow cells; ; monocyte; ; granulocyte; ; blood; ; right lung; ; spleen; ; germinal epithelium; ; right adrenal cortex;
	Top expressed in
	lip; ; skin of external ear; ; skin of abdomen; ; esophagus; ; skin of back; ; gastrula; ; cervix; ; perirhinal cortex; ; CA3 field; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; endonuclease activity; hydrolase activity; ribonuclease A activity; nucleic acid binding; lipopolysaccharide binding; ribonuclease activity; lyase activity;
Cellular component	extracellular region; lysosome; extracellular exosome; azurophil granule lumen;
Biological process	chemotaxis; RNA catabolic process; RNA phosphodiester bond hydrolysis, endonucleolytic; positive regulation of protein targeting to mitochondrion; neutrophil degranulation; induction of bacterial agglutination; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	6036
	54159
	ENSG00000169385
	ENSMUSG00000059606
	P10153
	O35292
	NM_002934
	NM_019398
	NP_002925
	NP_062271
	Wikidata
View/Edit Human	View/Edit Mouse

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.

The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein (RNASE3) from which it diverged ~50 million years ago after the split between the old world and the new world monkeys. It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.