RNASEH1

RNASEH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QK9, 2QKB, 2QKK, 3BSU
Identifiers
Aliases	RNASEH1, H1RNA, RNH1, PEOB2, ribonuclease H1
External IDs	OMIM: 604123; MGI: 1335073; HomoloGene: 2202; GeneCards: RNASEH1; OMA:RNASEH1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	3,558,333 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	28,709,588 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; middle temporal gyrus; ; nipple; ; visceral pleura; ; parietal pleura; ; Skeletal muscle tissue of biceps brachii; ; tibia; ; Brodmann area 23; ; gonad;
	Top expressed in
	Paneth cell; ; primary oocyte; ; saccule; ; otic placode; ; otic vesicle; ; secondary oocyte; ; neural layer of retina; ; primitive streak; ; zygote; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	nuclease activity; endonuclease activity; RNA-DNA hybrid ribonuclease activity; ribonuclease activity; hydrolase activity; magnesium ion binding; metal ion binding; RNA binding; nucleic acid binding;
Cellular component	cytoplasm; nucleus;
Biological process	nucleic acid phosphodiester bond hydrolysis; RNA catabolic process; DNA replication, removal of RNA primer; RNA phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	246243
	19819
	ENSG00000171865
	ENSMUSG00000020630
	O60930
	E9QLN8
NM_001286834; NM_001286837; NM_002936; NM_001378271; NM_001378272;
	NM_001378273
	NM_001286865; NM_011275
NP_001273763; NP_001273766; NP_002927; NP_001365200; NP_001365201;
	NP_001365202
	NP_001273794; NP_035405
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.