RNASET2

RNASET2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T0O
Identifiers
Aliases	RNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDs	OMIM: 612944; MGI: 3702087; HomoloGene: 31190; GeneCards: RNASET2; OMA:RNASET2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	166,957,191 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,278,698 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; blood; ; monocyte; ; spleen; ; parotid gland; ; seminal vesicula; ; olfactory bulb; ; lymph node; ; inferior ganglion of vagus nerve;
	Top expressed in
	right kidney; ; granulocyte; ; muscle of thigh; ; lip; ; zygote; ; esophagus; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; ribonuclease T2 activity; endonuclease activity; nuclease activity; RNA binding; ribonuclease activity; endoribonuclease activity;
Cellular component	lysosomal lumen; endoplasmic reticulum lumen; lysosome; endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; azurophil granule lumen;
Biological process	nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA catabolic process; RNA phosphodiester bond hydrolysis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8635
	68195
	ENSG00000026297
	ENSMUSG00000094724
	O00584
	Q5FWA0
	NM_003730; NM_017795; NM_018726
	NM_026611; NM_029204
	NP_003721
	NP_080887; NP_001077407; NP_080887
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene. It is a type of endoribonuclease.

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.