Rnd1

RND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CLS, 2REX, 3Q3J
Identifiers
Aliases	RND1, ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1
External IDs	OMIM: 609038; MGI: 2444878; HomoloGene: 8706; GeneCards: RND1; OMA:RND1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	48,865,870 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	98,575,342 bp
RNA expression pattern
	Top expressed in
	vena cava; ; right lobe of liver; ; frontal pole; ; prefrontal cortex; ; right frontal lobe; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	lumbar subsegment of spinal cord; ; granulocyte; ; primary visual cortex; ; morula; ; ventricular zone; ; cerebellar cortex; ; superior frontal gyrus; ; endothelial cell of lymphatic vessel; ; neural layer of retina; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; signaling receptor binding; protein binding; GTPase activity; protein kinase binding;
Cellular component	cytoplasm; adherens junction; cytosol; cytoskeleton; membrane; plasma membrane; actin cytoskeleton; intracellular membrane-bounded organelle; intracellular anatomical structure; cell cortex; cell division site;
Biological process	neuron remodeling; small GTPase mediated signal transduction; negative regulation of cell adhesion; actin filament organization; Rho protein signal transduction; regulation of cell shape; regulation of cell migration; establishment or maintenance of actin cytoskeleton polarity; regulation of actin cytoskeleton organization; actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	27289
	223881
	ENSG00000172602
	ENSMUSG00000054855
	Q92730
	Q8BLR7
	NM_014470
	NM_172612
	NP_055285
	NP_766200
	Wikidata
View/Edit Human	View/Edit Mouse

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]