Rnd3

RND3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M7B, 2V55, 4BG6
Identifiers
Aliases	RND3, ARHE, Rho8, RhoE, memB, Rnd3, Rho family GTPase 3
External IDs	OMIM: 602924; MGI: 1921444; HomoloGene: 21074; GeneCards: RND3; OMA:RND3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	150,539,011 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	51,039,123 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; stromal cell of endometrium; ; oral cavity; ; mucosa of pharynx; ; urethra; ; mucosa of urinary bladder; ; cervix epithelium; ; ganglionic eminence; ; human penis; ; lactiferous duct;
	Top expressed in
	genital tubercle; ; medial ganglionic eminence; ; tunica media of zone of aorta; ; molar; ; calvaria; ; mandibular prominence; ; cornea; ; atrioventricular valve; ; maxillary prominence; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; protein kinase binding;
Cellular component	Golgi membrane; Golgi apparatus; extracellular exosome; membrane; focal adhesion; intracellular anatomical structure; cytoplasm; plasma membrane; cell cortex; cell division site; intracellular membrane-bounded organelle;
Biological process	small GTPase mediated signal transduction; cell adhesion; actin cytoskeleton organization; actin filament organization; Rho protein signal transduction; regulation of cell shape; regulation of cell migration; establishment or maintenance of actin cytoskeleton polarity; regulation of actin cytoskeleton organization; actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	390
	74194
	ENSG00000115963
	ENSMUSG00000017144
	P61587
	P61588
	NM_005168; NM_001254738
	NM_028810
	NP_001241667; NP_005159
	NP_083086
	Wikidata
View/Edit Human	View/Edit Mouse

Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND3.

Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.