RNF123

RNF123
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA6
Identifiers
Aliases	RNF123, KPC1, FP1477, ring finger protein 123
External IDs	OMIM: 614472; MGI: 2148796; HomoloGene: 11112; GeneCards: RNF123; OMA:RNF123 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,721,529 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,960,545 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; right lobe of liver; ; triceps brachii muscle; ; body of tongue; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm;
	Top expressed in
	neural layer of retina; ; saccule; ; otic vesicle; ; muscle of thigh; ; fetal liver hematopoietic progenitor cell; ; lens; ; otic placode; ; cerebellar cortex; ; skeletal muscle tissue; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; transferase activity; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; cytosol; nuclear membrane;
Biological process	protein ubiquitination; protein deubiquitination; proteolysis involved in cellular protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	63891
	84585
	ENSG00000164068
	ENSMUSG00000041528
	Q5XPI4
	Q5XPI3
	NM_022064
	NM_032543; NM_001311152
	NP_071347
	NP_001298081; NP_115932
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).