RNF125

RNF125
Identifiers
Aliases	RNF125, TRAC-1, TRAC1, TNORS, ring finger protein 125, E3 ubiquitin protein ligase, ring finger protein 125
External IDs	OMIM: 610432; MGI: 1914914; HomoloGene: 32369; GeneCards: RNF125; OMA:RNF125 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	32,073,219 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; oocyte; ; secondary oocyte; ; parietal pleura; ; mucosa of sigmoid colon; ; superficial temporal artery; ; visceral pleura; ; white blood cell; ; monocyte; ; inferior ganglion of vagus nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; p53 binding; protein binding; transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity;
Cellular component	intracellular membrane-bounded organelle; membrane; Golgi membrane; Golgi apparatus; VCP-NPL4-UFD1 AAA ATPase complex;
Biological process	adaptive immune response; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; immune system process; ubiquitin-dependent protein catabolic process; negative regulation of type I interferon production; negative regulation of RIG-I signaling pathway; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	54941
	67664
	ENSG00000101695
	ENSMUSG00000033107
	Q96EQ8
	Q9D9R0
	NM_017831
	NM_026301; NM_001364973
	NP_060301
	NP_080577; NP_001351902
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.