RNF135

RNF135
Identifiers
Aliases	RNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDs	OMIM: 611358; MGI: 1919206; HomoloGene: 12427; GeneCards: RNF135; OMA:RNF135 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,999,911 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,090,583 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; parietal pleura; ; synovial membrane; ; visceral pleura; ; skin of arm; ; mucosa of ileum; ; secondary oocyte; ; gingival epithelium; ; human penis; ; synovial joint;
	Top expressed in
	proximal tubule; ; right kidney; ; epithelium of small intestine; ; granulocyte; ; interventricular septum; ; utricle; ; left lobe of liver; ; spleen; ; lacrimal gland; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	ribonucleoprotein complex binding; protein binding; metal ion binding; ubiquitin-protein transferase activity; identical protein binding; transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	positive regulation of interferon-beta production; negative regulation of type I interferon production; innate immune response; regulation of innate immune response; protein ubiquitination; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	84282
	71956
	ENSG00000181481
	ENSMUSG00000020707
	Q8IUD6
	Q9CWS1
	NM_001184992; NM_032322; NM_197939
	NM_028019
	NP_001171921; NP_115698; NP_922921
	NP_082295
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.