RNF2

RNF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H0D, 3GS2, 3H8H, 3IXS, 3RPG, 4R8P, 4S3O
Identifiers
Aliases	RNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B, LUSYAM
External IDs	OMIM: 608985; MGI: 1101759; HomoloGene: 2199; GeneCards: RNF2; OMA:RNF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	185,102,603 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	151,376,706 bp
RNA expression pattern
	Top expressed in
	gonad; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium; ; testicle; ; monocyte; ; Achilles tendon; ; epithelium of colon; ; buccal mucosa cell;
	Top expressed in
	genital tubercle; ; zygote; ; tail of embryo; ; medial ganglionic eminence; ; secondary oocyte; ; Gonadal ridge; ; mandibular prominence; ; atrioventricular valve; ; maxillary prominence; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; chromatin binding; RING-like zinc finger domain binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; transferase activity; zinc ion binding;
Cellular component	euchromatin; sex chromatin; ubiquitin ligase complex; nucleoplasm; chromosome; heterochromatin; MLL1 complex; PRC1 complex; PcG protein complex; nucleus; nuclear body;
Biological process	germ cell development; histone H2A-K119 monoubiquitination; regulation of transcription, DNA-templated; gastrulation with mouth forming second; histone H2A monoubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; protein ubiquitination; mitotic cell cycle; anterior/posterior axis specification; histone ubiquitination; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO
Orthologs
	6045
	19821
	ENSG00000121481
	ENSMUSG00000026484
	Q99496
	Q9CQJ4
	NM_007212
	NM_011277; NM_001360844; NM_001360845; NM_001360847
	NP_009143
	NP_035407; NP_001347773; NP_001347774; NP_001347776
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.