RNF20

RNF20
Identifiers
Aliases	RNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDs	OMIM: 607699; MGI: 1925927; HomoloGene: 5571; GeneCards: RNF20; OMA:RNF20 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	101,563,344 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	49,656,887 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; mucosa of ileum; ; deltoid muscle; ; caput epididymis; ; bronchial epithelial cell; ; parietal pleura; ; retinal pigment epithelium; ; corpus callosum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; blood; ; neural layer of retina; ; seminal vesicula; ; secondary oocyte; ; zygote; ; granulocyte; ; maxillary prominence; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; histone binding; p53 binding; chromatin binding; metal ion binding; mRNA 3'-UTR binding; protein binding; ubiquitin protein ligase binding; transferase activity; ubiquitin-protein transferase activity;
Cellular component	ubiquitin ligase complex; HULC complex; nucleolus; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of mRNA polyadenylation; positive regulation of histone methylation; ubiquitin-dependent protein catabolic process; protein polyubiquitination; positive regulation of transcription, DNA-templated; negative regulation of cell migration; regulation of mitotic cell cycle; histone H2B ubiquitination; positive regulation of histone H2B ubiquitination; histone ubiquitination; protein ubiquitination; histone monoubiquitination; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	56254
	109331
	ENSG00000155827
	ENSMUSG00000028309
	Q5VTR2
	Q5DTM8
	NM_019592
	NM_001163263; NM_182999; NM_001356401
	NP_062538
	NP_001156735; NP_892044; NP_001343330
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.