RNF216

RNF216
Identifiers
Aliases	RNF216, CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, ring finger protein 216
External IDs	OMIM: 609948; MGI: 1344349; HomoloGene: 19442; GeneCards: RNF216; OMA:RNF216 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	5,781,696 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,098,749 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; saphenous vein; ; sperm; ; stromal cell of endometrium; ; oocyte; ; granulocyte; ; Achilles tendon; ; secondary oocyte;
	Top expressed in
	spermatid; ; hand; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; otic vesicle; ; zygote; ; granulocyte; ; secondary oocyte; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; Schaffer collateral - CA1 synapse; postsynaptic endocytic zone; glutamatergic synapse;
Biological process	protein K48-linked ubiquitination; negative regulation of type I interferon production; viral process; regulation of interferon-beta production; protein ubiquitination; regulation of defense response to virus by host; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process; protein catabolic process, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	54476
	108086
	ENSG00000011275
	ENSMUSG00000045078
	Q9NWF9
	P58283
	NM_019011; NM_207111; NM_207116; NM_001377156
	NM_080561; NM_207110; NM_001359851
	NP_996994; NP_996999; NP_001364085
	NP_542128; NP_996993; NP_001346780
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.