RNF34

RNF34
Identifiers
Aliases	RNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDs	OMIM: 608299; MGI: 2153340; HomoloGene: 11839; GeneCards: RNF34; OMA:RNF34 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,430,623 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,009,354 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; triceps brachii muscle; ; glutes; ; ganglionic eminence; ; muscle of thigh; ; gonad; ; middle temporal gyrus; ; Brodmann area 23;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; tail of embryo; ; right ventricle; ; medial ganglionic eminence; ; genital tubercle; ; spermatid; ; granulocyte; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; phosphatidylinositol phosphate binding; p53 binding; ubiquitin protein ligase binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; endomembrane system; nucleus; membrane; plasma membrane; nuclear speck; nucleoplasm; cytosol; nuclear body;
Biological process	negative regulation of signal transduction by p53 class mediator; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; protein K48-linked ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; apoptotic process; regulation of oxygen metabolic process; cellular response to cold; protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	80196
	80751
	ENSG00000170633
	ENSMUSG00000029474
	Q969K3
	Q99KR6
	NM_194271; NM_001256858; NM_025126; NM_001394208
	NM_030564
	NP_001243787; NP_079402; NP_919247
	NP_085041
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.