RNF8

RNF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CSW, 2PIE, 4AYC, 4ORH, 4WHV
Identifiers
Aliases	RNF8, hring finger protein 8
External IDs	OMIM: 611685; MGI: 1929069; HomoloGene: 2944; GeneCards: RNF8; OMA:RNF8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	37,394,734 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,863,965 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; left testis; ; right testis; ; ventricular zone; ; islet of Langerhans; ; prefrontal cortex; ; gonad; ; right hemisphere of cerebellum; ; mucosa of esophagus;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; tail of embryo; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; neural layer of retina; ; endocardial cushion; ; mandibular prominence; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; histone binding; chromatin binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase binding; transferase activity; identical protein binding; zinc ion binding; ubiquitin binding; ubiquitin protein ligase activity;
Cellular component	site of double-strand break; ubiquitin ligase complex; nucleoplasm; chromosome; telomere; midbody; nucleus; cytosol; cytoplasm;
Biological process	response to ionizing radiation; histone H2A ubiquitination; interstrand cross-link repair; ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; positive regulation of DNA repair; histone H2A K63-linked ubiquitination; negative regulation of transcription elongation from RNA polymerase II promoter; cellular response to DNA damage stimulus; cell division; protein K48-linked ubiquitination; isotype switching; protein ubiquitination; spermatid development; cell cycle; histone H2B ubiquitination; double-strand break repair via nonhomologous end joining; histone exchange; protein autoubiquitination; double-strand break repair; DNA repair; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9025
	58230
	ENSG00000112130
	ENSMUSG00000090083
	O76064
	Q8VC56
	NM_003958; NM_183078
	NM_021419
	NP_003949; NP_898901
	NP_067394
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. RNF8 has activity both in immune system functions and in DNA repair.