ROBO1

ROBO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EO9, 2V9Q, 2V9T, 4HLJ
Identifiers
Aliases	ROBO1, DUTT1, SAX3, roundabout guidance receptor 1
External IDs	OMIM: 602430; MGI: 1274781; HomoloGene: 2206; GeneCards: ROBO1; OMA:ROBO1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	79,767,998 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	72,842,983 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; tibia; ; human penis; ; Achilles tendon; ; periodontal fiber; ; gingival epithelium; ; lateral nuclear group of thalamus; ; skin of hip; ; urethra;
	Top expressed in
	genital tubercle; ; cumulus cell; ; Gonadal ridge; ; habenula; ; vestibular membrane of cochlear duct; ; hair follicle; ; olfactory tubercle; ; maxillary prominence; ; left lung lobe; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	LRR domain binding; protein binding; identical protein binding; axon guidance receptor activity;
Cellular component	cytoplasm; integral component of membrane; cell projection; membrane; integral component of plasma membrane; cell surface; axon; plasma membrane; endoplasmic reticulum-Golgi intermediate compartment membrane;
Biological process	positive regulation of Rho protein signal transduction; negative regulation of chemokine-mediated signaling pathway; cell differentiation; negative regulation of mammary gland epithelial cell proliferation; Roundabout signaling pathway; positive regulation of axonogenesis; nervous system development; cell migration involved in sprouting angiogenesis; axon guidance; multicellular organism development; chemotaxis; heart development; cell adhesion; negative regulation of cell migration; negative regulation of negative chemotaxis; axon midline choice point recognition; activation of cysteine-type endopeptidase activity involved in apoptotic process; chemorepulsion involved in postnatal olfactory bulb interneuron migration; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of MAP kinase activity; positive regulation of vascular endothelial growth factor signaling pathway; outflow tract septum morphogenesis; aortic valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion formation; positive regulation of gene expression; negative regulation of gene expression; positive regulation of Notch signaling pathway involved in heart induction; aorta development; ventricular septum morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6091
	19876
	ENSG00000169855
	ENSMUSG00000022883
	Q9Y6N7
	O89026
	NM_001145845; NM_002941; NM_133631
	NM_019413
	NP_001139317; NP_002932; NP_598334
	NP_062286
	Wikidata
View/Edit Human	View/Edit Mouse

Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.