ROBO2

ROBO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UEM, 1UJT, 2EDJ
Identifiers
Aliases	ROBO2, SAX3, roundabout guidance receptor 2
External IDs	OMIM: 602431; MGI: 1890110; HomoloGene: 43188; GeneCards: ROBO2; OMA:ROBO2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	77,649,964 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	74,208,713 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; buccal mucosa cell; ; prefrontal cortex; ; islet of Langerhans; ; cartilage tissue; ; Brodmann area 46; ; Pons; ; endothelial cell; ; gonad;
	Top expressed in
	Rostral migratory stream; ; hand; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; neural layer of retina; ; ganglionic eminence; ; primary visual cortex; ; olfactory bulb; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; axon guidance receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; axolemma; extracellular exosome; plasma membrane;
Biological process	cell differentiation; ureteric bud development; kidney development; negative regulation of synapse assembly; Roundabout signaling pathway; positive regulation of axonogenesis; nervous system development; multicellular organism development; chemotaxis; central nervous system development; cellular response to hormone stimulus; olfactory bulb interneuron development; apoptotic process involved in luteolysis; negative regulation of negative chemotaxis; axon midline choice point recognition; metanephros development; homophilic cell adhesion via plasma membrane adhesion molecules; retinal ganglion cell axon guidance; brain development; spinal cord development; axon guidance; outflow tract septum morphogenesis; aortic valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion formation; positive regulation of Notch signaling pathway involved in heart induction; aorta development; ventricular septum morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6092
	268902
	ENSG00000185008
	ENSMUSG00000052516
	Q9HCK4
	Q7TPD3
NM_001128929; NM_001290039; NM_001290040; NM_001290065; NM_002942;
	NM_001378190; NM_001378191; NM_001378192; NM_001378193; NM_001378194; NM_001378195; NM_001378196; NM_001378197; NM_001378198; NM_001378199; NM_001378200; NM_001378201; NM_001378202; NM_001378203; NM_001394212; NM_001394213; NM_001394214; NM_001395656; NM_001395657
NM_175549; NM_001358490; NM_001358491; NM_001358492; NM_001358493;
	NM_001358494
NP_001122401; NP_001276968; NP_001276969; NP_001276994; NP_002933;
	NP_001365119; NP_001365120; NP_001365121; NP_001365122; NP_001365123; NP_001365124; NP_001365125; NP_001365126; NP_001365127; NP_001365128; NP_001365129; NP_001365130; NP_001365131; NP_001365132
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.