ROR1

ROR1
Identifiers
Aliases	ROR1, NTRKR1, dJ537F10.1, receptor tyrosine kinase-like orphan receptor 1, receptor tyrosine kinase like orphan receptor 1
External IDs	OMIM: 602336; MGI: 1347520; HomoloGene: 3675; GeneCards: ROR1; OMA:ROR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	64,181,498 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	100,301,962 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; popliteal artery; ; tibial arteries; ; islet of Langerhans; ; right coronary artery; ; lower lobe of lung; ; saphenous vein; ; Descending thoracic aorta; ; sural nerve; ; buccal mucosa cell;
	Top expressed in
	epithelium of lens; ; gastrula; ; umbilical cord; ; abdominal wall; ; decidua; ; medullary collecting duct; ; atrioventricular valve; ; efferent ductule; ; vestibular sensory epithelium; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; Wnt-protein binding; kinase activity; ATP binding; transferase activity; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; Wnt-activated receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	receptor complex; integral component of plasma membrane; integral component of membrane; membrane; stress fiber; cytoplasm; cell surface; plasma membrane; axon terminus; axon; cell projection;
Biological process	phosphorylation; protein phosphorylation; Wnt signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway, planar cell polarity pathway; peptidyl-tyrosine phosphorylation; astrocyte development; hearing; positive regulation of I-kappaB kinase/NF-kappaB signaling; inner ear development; positive regulation of NF-kappaB transcription factor activity; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	4919
	26563
	ENSG00000185483
	ENSMUSG00000035305
	Q01973
	Q9Z139
	NM_001083592; NM_005012
	NM_013845; NM_001312690
	NP_001077061; NP_005003
	NP_001299619; NP_038873
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.