ROR2

ROR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZZW, 4GT4
Identifiers
Aliases	ROR2, BDB, BDB1, NTRKR2, receptor tyrosine kinase like orphan receptor 2
External IDs	OMIM: 602337; MGI: 1347521; HomoloGene: 55831; GeneCards: ROR2; OMA:ROR2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	91,950,228 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	53,440,160 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; gastric mucosa; ; body of uterus; ; canal of the cervix; ; ectocervix; ; right ovary; ; gonad; ; left uterine tube; ; right auricle of heart; ; left ovary;
	Top expressed in
	primitive streak; ; muscle layer of urethra; ; external carotid artery; ; internal carotid artery; ; vas deferens; ; Paneth cell; ; dermis; ; condyle; ; endocardial cushion; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; frizzled binding; metal ion binding; kinase activity; Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; mitogen-activated protein kinase kinase kinase binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; clathrin-coated endocytic vesicle membrane; membrane; plasma membrane; integral component of plasma membrane; cytoplasm; microtubule; cell surface; dendrite; soma; axon; receptor complex;
Biological process	somitogenesis; skeletal system development; cell differentiation; cell fate commitment; SMAD protein signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; positive regulation of canonical Wnt signaling pathway; regulation of canonical Wnt signaling pathway; embryonic digit morphogenesis; Wnt signaling pathway; BMP signaling pathway; multicellular organism development; positive regulation of transcription, DNA-templated; embryonic genitalia morphogenesis; JNK cascade; protein phosphorylation; Wnt signaling pathway, calcium modulating pathway; inner ear morphogenesis; smoothened signaling pathway; negative regulation of canonical Wnt signaling pathway; cartilage condensation; signal transduction; negative regulation of cell population proliferation; peptidyl-tyrosine phosphorylation; Wnt signaling pathway, planar cell polarity pathway; astrocyte development; bone mineralization; male genitalia development; positive regulation of JUN kinase activity; positive regulation of macrophage differentiation; positive regulation of synaptic transmission, glutamatergic; positive regulation of protein kinase C activity; macrophage migration; negative regulation of signal transduction; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	4920
	26564
	ENSG00000169071
	ENSMUSG00000021464
	Q01974
	Q9Z138; Q8C3W2
	NM_004560; NM_001318204
	NM_013846
	NP_001305133; NP_004551
	NP_038874
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.