RPH3A

RPH3A
Identifiers
Aliases	RPH3A
External IDs	OMIM: 612159; MGI: 102788; HomoloGene: 7921; GeneCards: RPH3A; OMA:RPH3A - orthologs
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,148,155 bp
RNA expression pattern
	n/a
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; dorsal tegmental nucleus; ; superior colliculus; ; anterior horn of spinal cord; ; central gray substance of midbrain; ; medial vestibular nucleus; ; zygote;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; phosphatidylinositol phosphate binding; lipid binding; clathrin binding; syntaxin binding; calcium-dependent phospholipid binding; phosphatidylinositol-4,5-bisphosphate binding; zinc ion binding; inositol 1,4,5 trisphosphate binding; selenium binding; phosphate ion binding; calcium ion binding; protein-containing complex binding;
Cellular component	synapse; cell junction; membrane; Golgi apparatus; synaptic vesicle membrane; secretory granule; plasma membrane; synaptic vesicle; neuron projection; extrinsic component of membrane; cytosol; protein-containing complex; cytoplasmic vesicle; cell projection; dendritic spine; postsynaptic membrane; intracellular anatomical structure;
Biological process	protein transport; intracellular protein transport; calcium ion-regulated exocytosis of neurotransmitter; vesicle fusion; regulation of calcium ion-dependent exocytosis; spontaneous neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	22895
	19894
	ENSG00000089169
	ENSMUSG00000029608
	Q9Y2J0
	P47708
	NM_001143854; NM_014954
	NM_011286; NM_001302344; NM_001302345
NP_001137326; NP_055769; NP_001334881; NP_001334882; NP_001334883;
	NP_001334884
	NP_001289273; NP_001289274; NP_035416
	Wikidata
View/Edit Human	View/Edit Mouse

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.