60S ribosomal protein L6

RPL6
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 4D67, 4D5Y, 4UJE
Identifiers
Aliases	RPL6, L6, SHUJUN-2, TAXREB107, TXREB1, ribosomal protein L6
External IDs	OMIM: 603703; MGI: 3647789; HomoloGene: 31001; GeneCards: RPL6; OMA:RPL6 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,418,838 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gonad; ; islet of Langerhans; ; pituitary gland; ; Achilles tendon; ; lymph node; ; left ovary; ; smooth muscle tissue; ; monocyte;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; structural constituent of ribosome; cadherin binding; RNA binding;
Cellular component	cytosol; ribosome; membrane; focal adhesion; intracellular anatomical structure; cytoplasmic ribonucleoprotein granule; cytosolic large ribosomal subunit; nucleus; cytoplasm; endoplasmic reticulum; rough endoplasmic reticulum; postsynaptic density; polysomal ribosome; synapse;
Biological process	cytoplasmic translation; regulation of transcription, DNA-templated; protein biosynthesis; viral transcription; SRP-dependent cotranslational protein targeting to membrane; ribosomal large subunit assembly; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6128
	432502
	ENSG00000089009
	n/a
	Q02878
	n/a
NM_000970; NM_001024662; NM_001320137; NM_001320138; NM_001320139;
	NM_001320140; NM_001320141; NM_001320142
	XM_036156129
NP_000961; NP_001019833; NP_001307066; NP_001307067; NP_001307068;
	NP_001307069; NP_001307070; NP_001307071
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.